hub sciencedirect scopus applications register login login go to scival suite username: password: remember me | not registered? buy generic viagra Forgotten your username or password? cialis and viagra generic Go to athens / institution login remote access activation home publications search my settings my alerts shopping cart help export citation purchase more options... Email article signed up for journal alerts [remove] alert me about new articles in this journal your selection(s) could not be saved due to an internal error. online doctor prescription for viagra Please try again. natural products like viagra Search     all fields     author advanced search     journal/book title     volume   issue   page search tips article outline is loading... Javascript required for article outline volume 11, issue 6, june 2012, pages 535–544 review aquaporin 4 and neuromyelitis optica dr marios c papadopoulos, md a , , , prof as verkman, md b a academic neurosurgery unit, st george's, university of london, london, uk b department of medicine and department of physiology, university of california san francisco, san francisco, ca, usa available online 16 may 2012 how to cite or link using doi permissions & reprints view full text purchase $31. generic viagra canada 50 introduction epidemiology aqp4: the target of antibodies mechanisms of pathogenesis unanswered questions and controversies treatment strategies future directions search strategy and selection criteria references summary neuromyelitis optica is an inflammatory demyelinating disorder of the cns. The discovery of circulating igg1 antibodies against the astrocyte water channel protein aquaporin 4 (aqp4) and the evidence that aqp4-igg is involved in the development of neuromyelitis optica revolutionised our understanding of the disease. order viagra online However, important unanswered questions remain—for example, we do not know the cause of aqp4-igg-negative disease, how astrocyte damage causes demyelination, the role of t cells, why peripheral aqp4-expressing organs are undamaged, and how circulating aqp4-igg enters neuromyelitis optica lesions. viagra generic safe New drug candidates have emerged, such as aquaporumab (non-pathogenic antibody blocker of aqp4-igg binding), sivelestat (neutrophil elastase inhibitor), and eculizumab (complement inhibit. cheap viagra viagra for sale